El Prof. Obeso es el investigador principal de unos de los grupos de investigación de esta red nacional, promovida por el ISCIII, desde su creación en 2008. Las actividades del grupo han sido valoradas como “Excelentes” en todas las evaluaciones.

    Como parte de su colaboración con CIBERNED, estamos llevando a cabo el proyecto: “Onset and progression of Parkinson’s disease: role of glial activation”, con la Dra. M.C. Rodríguez Oroz , como investigadora principal, y junto al Prof. C. Matute (Achucarro Centre of Neurosciences, Universidad del País Vasco) y Prof. M. Rodríguez de la Univ. De la Laguna (Tenerife).


    Prof. Carmen Cavada (Department of Anatomy, Histology and Neurosciences) collaborates on a basic project since 2004. The project has made it possible to create a gradual model of dopaminergic deficit that mimics the main phases of Parkinson’s disease. Currently, we are working on defining extra-striatal compensatory mechanisms in early stages (pre-symptomatic) of the neurodegenerative process.


    Prof. Rodríguez Díaz, Department of Physiology. Over the latest 20 years, he has been performing regular and far-reaching studies of the neuronal mechanisms of basal ganglia associated to Parkinson’s disease. We are currently working together in the context of a CIBERNET project.


    Prof. M.T. Herrero, Department of Histology and Anatomy. Prof. Herrero began working on the MPTP model with Prof. Obeso in the 90s, making original and valuable contributions to the anatomo-functional characterisation of striopallidal circuits in the Parkinson condition, in collaboration with Prof. Agid’s group (Paris). From Murcia, the Professor has continued collaborating, describing for example the absence of Lewy bodies in MPTP models after 10 years of lesion progression. Currently, the Professor is an essential participant in a study designed to create a model of synucleinopathy and demonstrate the prion characteristics of the process.


    University of Medical Sciences of La Habana, Dr. N. Pavón, Dr. Casabona, Dr. Rodriguez-Rojas, Dr. R. Macías. Study of the effects of focal lesions to basal ganglia on mobility and behaviour. From 1995 to date.


    We began working closely with Prof. Redgrave in 2008, which resulted in a study published in Nature Reviews Neuroscience and a hypothesis on the compensation of the dopaminergic striatal through the prefrontal voluntary system (goal directed system). Recently and as a result of that hypothesis, a study has been initiated with Dr. T. Stafford, also of Sheffield University sponsored by the MJFox Foundation on the typing methods of patients with Parkinson’s disease.


    There is a cooperation project with Prof. Bezard that has been in place for a number of years comprising joint studies and publications related mainly with the origin and physiopathology of Levodopa-induced dyskinesia in Parkinson’s disease.

    There is currently an ambitious project underway, financed partly by the MJFox based on the prion transmission of proteins such as alpha-synuclein in Parkinson’s disease. This study was carried out in the University of Murcia in cooperation with Prof. Herrero.

    In parallel and as a consequence of this project, a cooperation project has begun with the University of the Basque Country (Prof. Matute and Dr. F. Cavaliere, Achucarro Institute of Neurosciences, Vizcaya) where there is an additional study on the transmission of synuclein in neuronal and glia cultures.

    Prof. T. Boraud. In 2014 began a cooperative project to study a very recent model of the mechanisms associated to learning habitual motor tasks and the changes that occur on inducing a dopaminergic deficit. It is a model in which a rhesus monkey learns to drive a vehicle (an adapted wheelchair) following rules similar to those that apply when humans are driving. When the tasks are performed they are recorded and the neuronal activity in the basal ganglia are studied along with the effects of dopaminergic blocking through local striatal administration of pharmaceuticals. Dr. Steffanie Etinne has received a grant from the Hospitales de Madrid Foundation to carry out this project.


    We are currently working with Prof Rosario Moratalla, Laboratory of Neurobiology of basal ganglia, on defining the molecular base of levodopa-induced dyskinesias in Parkinson’s disease and on a new project using optogenetics to delimit the changes in learnt behaviour (habitual) vs. intended (“goal-directed”), which accompany a dopaminergic deficit in a model of Parkinson’s disease.


    Prof. R. Costa.  In 2014, we began working with the group of Prof. Costa, an international authority on the study of basal ganglia. His team has developed functional evaluation techniques of dopaminergic neurons “in vivo”, which are very important for understanding the mechanisms of selective vulnerability in substantia nigra in Parkinson’s disease.


    Dr. Antonio Oliviero. In 2014, we also began working with the group of Dr. Oliviero, an international authority on the development and application of non-invasive neurostimulation techniques in humans. Dr. Oliviero’s team has invented a new portable and low-cost neurostimulation technique, transcranial static magnetic field stimulation (tSMS), which has great potential for the development of new “magneceutic” treatments for Parkinson’s disease.