HM CINAC is dedicated to translational research. The Centre has a clinical assistance area, a clinical and experimental research area and a teaching area.

The activities of the HM CINAC have the following objectives:

1. Research in Clinical Neuroscience, focused on neurodegenerative diseases such as Parkinson’s disease, cognitive impairment and behavioural disorders with a comprehensive approach. We apply advanced neuroimaging methods (integrated fMRI-PET), neurophysiology (non-invasive neurostimulation, movement studies and registration of oscillatory activity), neurocognitive stimulation (behavioural laboratory) and neurosurgical stimulation (deep brain stimulation, focal ultrasound therapy) to advance in the clinical and pathophysiological studies and to develop new therapeutic options for Parkinson’s disease and other neurodegenerative pathologies, as well as movement and behavioural disorders (dystonia, myoclonus, pathological impulsivity, Gilles de la Tourette syndrome, etc.).

2. Development of fundamental knowledge through Experimental Neuroscience, for which HM CINAC has a pre-clinical research centre working on neurobiological mechanisms of neurological diseases. This approach is based on neuroimaging methods (PET and fMRI), neurophysiological techniques that enable comprehensive unitary, multiple and field potential neuronal activity studies, behavioural laboratories and histopathological techniques.

3. Series of national and international collaborations that create a joint direction and network with the common objective of advancing in the fight against neurodegenerative diseases and neurofunctional disorders.

Scientific Objectives

The HM CINAC has clinical care and research on clinical-experimental set-ups as integrated objective in a homogenous and transversal group. The effort is unique and directly focused on developing pathophysiologic concepts that will achieve therapeutic advances to help improve the quality of life of patients. In this initial period, HM CINAC specific interest is focused on stopping the progression of Parkinson’s disease based on functional neuroscience studies, focal ultrasound, genetics, magnetic stimulation, cognitive impairment and experimental neurology.

Clinical Services

The Clinical Neurosciences section offers the study and treatment of neurodegenerative diseases in an outpatient clinic, day hospital and general hospital. There are Specialist Programmes in:

a) Study and treatment of Parkinson’s disease and movement disorders;
b) Cognitive Impairment (in cooperation with the Psychiatry service);
c) Behavioural Disorders (in cooperation with the Psychiatry service);
d) Advanced neurophysiological studies on motor control, cognition and behaviour;
e) Functional neurosurgery: Deep Brain Stimulation, Focal Ultrasound and traditional ablative surgery.

Main Areas of Work

• Selective vulnerability of dopaminergic neurons in ventrolateral substantia nigra pars compacta: Anatomical-physiological factors and mechanisms.
• Anatomo-functional base of automatic movements:  Neurosciences of normal or routine activities.
• Compensatory Mechanisms, Inflammation and progression of Parkinson’s disease.
• Onset and progression of Parkinson’s disease: cognitive-motor pattern and structural and functional correlation.
• Bases of pathological impulsivity and Parkinson’s disease: Mechanisms and treatment.
• New Therapeutic Perspectives in Parkinson’s disease:

a) Impact of early functional recovery by means of ultrasound.
b) Value of Magneto-ceutics in the treatment of Parkinson’s disease.

• Impact of preferential and multidisciplinary care in Parkinson’s disease: Comparison of patients with early vs. late onset.